Intractable Rare Dis Res. 2021;10(2):109-113. (DOI: 10.5582/irdr.2021.01054)

Loss of miR-23a cluster in skeletal muscle can suppress bone remodeling

Zhang H, Luan J, Cui Y, Han J


Muscle-bone interaction might regulate bone remodeling in an endocrine manner, but the exact mediators have not been identified. Previous in vitro studies suggest that exosomal miRNAs are a candidate for this interaction. Here we present an in vivo study to show that targeted knockout of a muscle-specific miR-23a cluster including miR-23a, miR-27, and miR-24-2 in skeletal muscle tissues can suppress bone remodeling in mice. The effect of miR-23a cluster seem to not be related to aging, but can worsen the pathological extent of osteoporosis in mice. Our findings suggest that muscle-derived miRNAs may contribute to bone metabolism regulation through exosomes in muscle-bone interaction.

KEYWORDS: exosome, microRNA, muscle-bone interaction, bone remodeling

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